Size-Selective PDRN Fractionation Using Charge-Tunable Chitosan-Based Magnetic Nanoclusters

Chitosan-based magnetic nanoclusters (CMNCs) with a tunable surface charge sort polydeoxyribonucleotides (PDRNs) by molecular weight through differential electrostatic binding. A simple magnet then separates each size fraction within minutes while fully preserving PDRN bioactivity, providing the size-defined PDRN needed for molecular-weight-dependent therapeutic studies. 

Enhanced Virus Capture Using CMNC-Loaded Polydopamine-Coated Nylon Mesh

Positively charged magnetic nanoclusters (CMNCs) immobilized on a polydopamine-coated nylon mesh capture viruses directly from flowing fluid. Negatively charged virus particles are drawn in by electrostatic attraction while non-target proteins pass through, and tuning the flow rate and pH further boosts capture — a simple, rapid route to concentrate and separate viruses. 

A self-propelled oral vaccine nanomotor for gut mucosal immunity 

ActiPSomes are magnesium-powered polymersome nanomotors that survive the stomach and self-activate in the intestine: an enteric coating shields the antigen from gastric acid, while pH-triggered propulsion switches on in the gut — all built from biodegradable PLA. In preclinical tests they enhanced antigen uptake and markedly increased PEDV-specific intestinal and fecal IgA responses with no observable toxicity, pointing to a fuel-efficient, biodegradable platform for oral mucosal vaccines.